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GEROPROTECT® Longevity A.I.™ - 30 Softgels

30 Gelcaps
In Stock
In stock

Longevity A.I.™ is the latest collaboration between Insilico Medicine, Inc. and Life Extension. This unique formula targets many of the same anti-aging pathways as calorie restriction diets, which have a strong correlation with enhanced longevity and health. Deep learning analysis conducted by Insilico has identified withaferin A, gamma-linolenic acid, and ginsenoside Rg3 as potent compounds with the potential to fight back against the biological effects of aging… and for the first time, Life Extension has combined them into a single formula: Longevity A.I.™

Benefits at a Glance:

  • Provides many of the same longevity benefits as calorie restriction
  • Contains three botanical compounds identified by artificial intelligence
  • Unique ingredients combine to address common aging pillars
  • Supports healthy stem cells, molecular integrity, and cell metabolism
  • Promotes healthy inflammation response and youthful gene expression
  • Helps your body maintain proteostasis and adapt to stress  

Longevity A.I.™ is part of our GEROPROTECT® line. It works by targeting all seven aging pillars. These pillars represent the interconnected aspects of biological aging. By addressing the physical and chemical consequences of getting older, Longevity A.I.™ can help you live a longer, healthier, and happier life. Add Longevity A.I.™ to your long-term health regimen today.

More facts about Longevity A.I.™

Calorie restriction has been shown to enhance healthspan, but it is difficult to adhere to such demanding dietary parameters and get the optimal nutrition your body needs. So those looking to improve their healthy lifespan have sought out calorie restriction mimetics, or compounds which can effectively mimic the benefits of calorie restriction. Until now, that search has been slow.

21st century technology from Insilico Medicine, inc.

Insilico Medicine is a medical technology company that has created a database of research on over two hundred geroprotectors, or compounds thought to be capable of inhibiting aging at the cellular level. Then, they use a proprietary algorithm based on 21st century artificial intelligence computing techniques to score these compounds' impact on pathways associated with normal aging. When asked to rate various compounds to find the ones best suited to reproduce the benefits of a calorie restriction mimetic, Insilico identified withaferin A from ashwaganda, gamma-linolenic acid from borage seed oil, and ginsenoside Rg3 from ginseng. Without Insilico, this process could have taken decades.

The seven pillars of aging

The three compounds identified by Insilico that are included in Longevity A.I.™ work together to address the seven “aging pillars,” or major contributing factors to the biological effects of aging:

Molecular Integrity - The molecules in our cells such as DNA and RNA, proteins, and essential lipids are delicate. As we age oxidation, UV radiation, glycating agents, and other factors can damage these sensitive molecules. Maintaining their integrity is essential to healthy aging.

Epigenetics – Youthful gene expression helps hold back the hand of time. But diet and other environmental influences can not only change the way these longevity genes are expressed, but also destabilize them. So maintaining youthful gene expression is essential to a healthy life span.

Proteostasis – Think of protein homeostasis as a “quality control network” that helps ensure the integrity of proteins within our cells. The cell signaling pathways that affect longevity and youthfulness strongly influence proteostasis as well, making it an integral part of healthy aging.

Inflammation response – Inflammation is one of our body's natural biological defenses. But too much of a good thing can be harmful, and can lead to undesirable aspects of the aging process. So it's important to encourage our body's healthy response to inflammation as we age.

Adapting to stress – We're continually exposed to physical, environmental, and psychological stressors, to which our bodies physically respond. As we age, it's important to help our bodies deal with physical and emotional stress in a healthy, constructive way.

Stem cell health – Stem cells operate as kind of an internal repair system. When some cells in our bodies become old or damaged, they are replaced by stem cells that have transformed into the cell they are replenishing. But as we age, effectiveness of stem cell replacement and tissue regeneration is reduced. So maintaining healthy stem cell activity is essential to our health.

Healthy metabolism – Cells produce energy our bodies need at a cost to their environment, which is us. Natural pathways exist to counteract the byproducts of cellular energy production, but they become less efficient as we age. Maintaining these pathways is essential to youthful cellular metabolism. 

Synergistic ingredients target anti-aging pathways

Remember, these seven pillars are interconnected. So it makes sense that an effective nutritional formula for healthy aging would need to address each aspect of the normal aging process. That's the beauty of Longevity A.I.™'s three unique ingredients: they work together to do just that.

Based on data from Insilico Medicine's sophisticated screening platform, we can categorize each compound's benefits as follows: Ginsenoside Rg3 supports molecular integrity. Withaferin A supports proteostasis, while gamma-linolenic acid helps maintain youthful gene expression.

Withaferin A, gamma-linolenic acid and ginsenoside Rg3 all promote healthy cell metabolism. Gamma-linolenic acid together with withaferin A help to maintain a youthful and natural stress response. And Gamma-linolenic acid together with ginsenoside Rg3 are powerful inhibitors of unwanted inflammatory factors They also contribute to healthy stem cell activity.

Quick Reference: Longevity A.I. Ingredients

  • Supports molecular integrity:
    Ginsenoside Rg3
  • Maintains youthful gene expression:
    Gamma-linolenic acid
  • Supports proteostasis:
    Withaferin A
  • Supports a healthy inflammatory response:
    Gamma-linolenic acid, Ginsenoside Rg3
  • Helps maintain a healthy stress response:
    Gamma-linolenic acid, Withaferin A
  • Supports stem cell health:
    Gamma-linolenic acid, Ginsenoside Rg3
  • Promotes healthy cell metabolism:
    Withaferin A, Gamma-linolenic acid, Ginsenoside Rg3

Longevity A.I.: nutritional supplement for longer life

Longevity A.I.™ represents a unique step in geroprotective nutrition for a youthful, healthy lifespan. It's also the only once-daily supplement that provides all three of these unique ingredients in a single convenient formula. Add it to your long-term regimen today.

Serving Size 1 softgel

Amount Per Serving

  • Gamma-linolenic acid (GLA) [from borage oil (seed)] 300 mg
  • Ginsenosides Rg3 [from Asian ginseng (Panax) C.A. Mey. extract (stem, leaf) (std. to 10% ginsenosides Rg3)] 20 mg
  • Withaferin A [from ashwagandha extract (root, leaf) (std. to 3% withaferin A)] 12 mg

Other ingredients: gelatin, medium chain triglycerides, glycerin, purified water, sunflower lecithin, maltodextrin, yellow beeswax, carob color, hydroxypropyl methylcellulose, silica. Non-GMO.

Take one (1) softgel daily, or as recommended by a healthcare practitioner.



Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.